Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC028
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-29 15:45
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tblMadopar 250mg4x1/2,capsMadopar HBS125mgx2,tbl Mirapexin 0,52mg1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 11, 'TN': 8, 'TP': 31, 'FP': 22}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 20.672
timePerCircleCoV 0.179099
timePerCircleSlope 0.0379726
meanError 1.42122
tremorFreq 5.85938
tremorRelPower 30.2585
tremorGyroAmpMean 0.0180943
tremorGyroAmpSlope -0.000394982
tremorGyroAmpCoV 0.381414
tremorCoordAmpMean 0.0351753
tremorCoordAmpSlope -0.00114284
tremorCoordAmpCoV 0.395735
tremorAccAmpMean 0.0508358
tremorAccAmpSlope -0.000186201
tremorAccAmpCoV 0.146143
tremorPcRelVar 0.703151
tremorPcX 0.213387
tremorPcY -0.976968

Circle Segment 1

Duration 17.8 s, Accuracy Estimate 1.339 (lower is better)

Circle Segment 2

Duration 18.84 s, Accuracy Estimate 1.425 (lower is better)

Circle Segment 3

Duration 16.56 s, Accuracy Estimate 1.132 (lower is better)

Circle Segment 4

Duration 18.44 s, Accuracy Estimate 1.7 (lower is better)

Circle Segment 5

Duration 17.4 s, Accuracy Estimate 1.122 (lower is better)

Circle Segment 6

Duration 22.88 s, Accuracy Estimate 1.456 (lower is better)

Circle Segment 7

Duration 23.08 s, Accuracy Estimate 0.994 (lower is better)

Circle Segment 8

Duration 27.8 s, Accuracy Estimate 1.508 (lower is better)

Circle Segment 9

Duration 24.64 s, Accuracy Estimate 1.288 (lower is better)

Circle Segment 10

Duration 19.28 s, Accuracy Estimate 2.248 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 52.96
timePerSpiralCoV 0.107923
timePerSpiralSlope -0.0351208
meanError 1.81099
tremorFreq 5.66406
tremorRelPower 32.3523
tremorGyroAmpMean 0.0218873
tremorGyroAmpSlope 0.000200634
tremorGyroAmpCoV 0.449922
tremorCoordAmpMean 0.0391322
tremorCoordAmpSlope -0.000253003
tremorCoordAmpCoV 0.384135
tremorAccAmpMean 0.0833039
tremorAccAmpSlope -3.11307e-06
tremorAccAmpCoV 0.0779053
tremorPcRelVar 0.646177
tremorPcX -0.137926
tremorPcY -0.990443

Spiral Segment 1

Duration 54.04 s, Accuracy Estimate 2.04 (lower is better)

Spiral Segment 2

Duration 58.52 s, Accuracy Estimate 1.649 (lower is better)

Spiral Segment 3

Duration 56.4 s, Accuracy Estimate 2.303 (lower is better)

Spiral Segment 4

Duration 43.68 s, Accuracy Estimate 1.58 (lower is better)

Spiral Segment 5

Duration 52.16 s, Accuracy Estimate 1.482 (lower is better)

Elel

eDurationMean 0.450921
eDurationStd 0.137859
eDurationStdnorm 0.305728
eDurationMedian 0.41
eDurationQuartdelta 0.075
eDurationQuartdeltanorm 0.182927
eDurationKurt 10.7827
eDurationTrenddiff -0.065
eDurationTrendratio 0.855556
eWidthMean 3.13745
eWidthStd 1.03291
eWidthStdnorm 0.329219
eWidthMedian 2.9835
eWidthQuartdelta 1.053
eWidthQuartdeltanorm 0.352941
eWidthKurt 5.98311
eWidthTrenddiff 0.117
eWidthTrendratio 1.04
eHeightMean 8.12226
eHeightStd 1.58067
eHeightStdnorm 0.19461
eHeightMedian 7.956
eHeightQuartdelta 1.521
eHeightQuartdeltanorm 0.191176
eHeightKurt 5.03775
eHeightTrenddiff 0.468
eHeightTrendratio 1.06154
eAspectMean 0.385
eAspectStd 0.0928843
eAspectStdnorm 0.241258
eAspectMedian 0.375812
eAspectQuartdelta 0.106767
eAspectQuartdeltanorm 0.284097
eAspectKurt 4.81108
eAspectTrenddiff 0.015625
eAspectTrendratio 1.04167
eSlantMean -0.128441
eSlantStd 0.146625
eSlantStdnorm -1.14157
eSlantMedian -0.10119
eSlantQuartdelta 0.211544
eSlantQuartdeltanorm -2.09055
eSlantKurt 3.14344
eSlantTrenddiff 0.156522
eRtopMean 0.546667
eRtopStd 0.159836
eRtopStdnorm 0.292384
eRtopMedian 0.550862
eRtopQuartdelta 0.197917
eRtopQuartdeltanorm 0.359285
eRtopKurt 3.76319
eRtopTrenddiff 0.0820513
eRbotMean 0.914307
eRbotStd 0.359392
eRbotStdnorm 0.393076
eRbotMedian 0.816667
eRbotQuartdelta 0.369048
eRbotQuartdeltanorm 0.451895
eRbotKurt 4.33837
eRbotTrenddiff -0.307692
eRrightMean 0.773331
eRrightStd 0.0861514
eRrightStdnorm 0.111403
eRrightMedian 0.76687
eRrightQuartdelta 0.122105
eRrightQuartdeltanorm 0.159225
eRrightKurt 2.53234
eRrightTrenddiff 0.0278586
eRleftMean 0.532609
eRleftStd 0.139433
eRleftStdnorm 0.261792
eRleftMedian 0.507246
eRleftQuartdelta 0.124786
eRleftQuartdeltanorm 0.246007
eRleftKurt 4.77437
eRleftTrenddiff -0.10101
lDurationMean 0.66875
lDurationStd 0.195044
lDurationStdnorm 0.291654
lDurationMedian 0.6175
lDurationQuartdelta 0.1825
lDurationQuartdeltanorm 0.295547
lDurationKurt 9.69397
lDurationTrenddiff -0.1725
lDurationTrendratio 0.762887
lWidthMean 3.79957
lWidthStd 1.07493
lWidthStdnorm 0.282909
lWidthMedian 3.51
lWidthQuartdelta 1.17
lWidthQuartdeltanorm 0.333333
lWidthKurt 3.2901
lWidthTrenddiff -0.9945
lWidthTrendratio 0.763889
lHeightMean 16.9562
lHeightStd 3.47799
lHeightStdnorm 0.205116
lHeightMedian 16.263
lHeightQuartdelta 3.1005
lHeightQuartdeltanorm 0.190647
lHeightKurt 5.05917
lHeightTrenddiff -2.1645
lHeightTrendratio 0.874576
lAspectMean 0.224453
lAspectStd 0.0454645
lAspectStdnorm 0.202557
lAspectMedian 0.2298
lAspectQuartdelta 0.0521694
lAspectQuartdeltanorm 0.22702
lAspectKurt 3.95802
lAspectTrenddiff -0.019644
lAspectTrendratio 0.917028
lSlantMean -0.149
lSlantStd 0.0984112
lSlantStdnorm -0.660479
lSlantMedian -0.153976
lSlantQuartdelta 0.139741
lSlantQuartdeltanorm -0.907552
lSlantKurt 2.79314
lSlantTrenddiff 0.0895701
lRtopMean 0.577899
lRtopStd 0.15368
lRtopStdnorm 0.265929
lRtopMedian 0.583426
lRtopQuartdelta 0.214348
lRtopQuartdeltanorm 0.367395
lRtopKurt 2.28893
lRtopTrenddiff 0.0437286
lRbotMean 1.28798
lRbotStd 0.414549
lRbotStdnorm 0.321859
lRbotMedian 1.24169
lRbotQuartdelta 0.5619
lRbotQuartdeltanorm 0.452529
lRbotKurt 2.71201
lRbotTrenddiff -0.103594
lRrightMean 0.754436
lRrightStd 0.115733
lRrightStdnorm 0.153403
lRrightMedian 0.768707
lRrightQuartdelta 0.162458
lRrightQuartdeltanorm 0.211339
lRrightKurt 3.30882
lRrightTrenddiff 0.043064
lRleftMean 0.575854
lRleftStd 0.144721
lRleftStdnorm 0.251315
lRleftMedian 0.599945
lRleftQuartdelta 0.196056
lRleftQuartdeltanorm 0.326791
lRleftKurt 2.87469
lRleftTrenddiff -0.0680638

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.96544
sumTouchScores 14.4816
meanMovementTime 1.1925
numTouches 15
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.877483
sumTouchScores 11.4073
meanMovementTime 1.41
numTouches 13
undershootPercentage 7.69231
overshootPercentage 0

ZigZag

numZigzags 4
timePerZigzagMean 43.18
timePerZigzagCoV 0.358857
timePerZigzagSlope 0.235665
meanError 2.02516
tremorFreq 5.85938
tremorRelPower 38.7529
tremorGyroAmpMean 0.0367471
tremorGyroAmpSlope -0.00238924
tremorGyroAmpCoV 0.474797
tremorCoordAmpMean 0.089871
tremorCoordAmpSlope -0.00390512
tremorCoordAmpCoV 0.756032
tremorAccAmpMean 0.0658227
tremorAccAmpSlope -0.000896237
tremorAccAmpCoV 0.243471
tremorPcRelVar 0.841407
tremorPcX 0.136194
tremorPcY 0.990682

ZigZag Segment 1

Duration 34.8 s, Accuracy Estimate 2.042 (lower is better)

ZigZag Segment 2

Duration 31.64 s, Accuracy Estimate 2.272 (lower is better)

ZigZag Segment 3

Duration 40.52 s, Accuracy Estimate 1.929 (lower is better)

ZigZag Segment 4

Duration 65.76 s, Accuracy Estimate 1.857 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 20.784
timePerZigzagCoV 0.147317
timePerZigzagSlope -0.0887221
zigzagHeightMean 59.9998
zigzagHeightCoV 0.048362
zigzagHeightSlope -0.0291254
meanError 0.0389828
tremorFreq 5.85938
tremorRelPower 37.743
tremorGyroAmpMean 0.063339
tremorGyroAmpSlope 0.000494827
tremorGyroAmpCoV 0.483762
tremorCoordAmpMean 0.204965
tremorCoordAmpSlope 0.000998954
tremorCoordAmpCoV 0.835899
tremorAccAmpMean 0.0998458
tremorAccAmpSlope 0.000519691
tremorAccAmpCoV 0.352365
tremorPcRelVar 0.828694
tremorPcX -0.0755611
tremorPcY 0.997141

ZigZag Offset Segment 1

Duration 25.44 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 2

Duration 21.44 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 3

Duration 21.0 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 4

Duration 18.2 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 5

Duration 17.84 s, Accuracy Estimate 0.035 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.73}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.48679617412079357}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8949969111538516}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8015260902824735}